Publications
Publications within the network or with several authors from the network
Microbiotoxicity: Antibiotic Usange and its Unintended Harm to the Microbiome.
Theodosiou AA, Jones CE, Read RC, Bogaert D.
Curr Opin Infect Dis. 2023 Oct 1;36(5):371-378. doi: 10.1097/QCO.0000000000000945. Epub 2023 Jul 25.
Mode of Delivery Modulates the Intestinal Microbiota and Impacts the Response to Vaccination.
De Koff EM, Van Baarle D. Van Houten MA, Reyman M, Berbers GAM, Van den Ham F, Chu MLJN, Sanders EAM, Bogaert D, Fuentes S.
Nat Commun. 2022 Nov 15;13(1):6638. doi: 10.1038/s41467-022-34155-2.
Immune-Microbe Interactions Early in Life: A Determinant of Health and Disease Long Term.
Brodin P.
Science. 2022 May 27;376(6596):945-950. doi: 10.1126/science.abk2189.Epub 2022 May 26.
Longitudinal Analyses of Development of the Immune System During the First Five Years of Life in Relationship to Lifestyle.
Olin A, Acevedo N, Lakshmikanth T, Chen Y, Johansson C, Alm J, Scheynius A, Brodin P.
Allergy. 2022 May;77(5):1583-1595. doi: 10.1111/all.15232. Epub 2022 Feb 16.
Machine Learning Used to Compare the Diagnostic Accuracy of Risk Factors, Clinical Signs and Biomarkers and to Develop a New Prediction Model for Neonatal Early-onset Sepsis.
Stocker M, Daunhawer I, van Herk W, El Helou S, Dutta S, Schuerman FABA, van den Tooren-de RK, Wieringa JW, Janota J, van der Meer-Kappelle LH, Moonen R, Sie SD, de Vries E, Donker AE, Zimmerman U, Schlapbach LJ, Amerik C, Hoffmann-Haringsma A, Roy M, Tomaske M, Kornelisse RF, van Gijsel J, Plötz FB, Wellmann S, Achten NB, Lehnick D, van Rossum AMC, Vogt JE.
Pediatr Infect Dis J. 2022 Mar 1;41(3):248-254. doi: 10.1097/INF.0000000000003344.
Effects of Early-life Antibiotics on the Developing Infant Gut Microbiome and Resistome: A Randomized Trial.
Reyman M, Van Houten MA, Watson RL, Chu MLJN, Arp K, De Waal WJ, Schiering I, Plötz FB, Willems RJL, Van Schaik W, Sanders EAM, Bogaert D.
Nat Commun. 2022 Feb 16;13(1):893. doi: 10.1038/s41467-022-28525-z.
Cost Impact of Procalcitonin-guided Decision Making on Duration of Antibiotic Therapy for Suspected Early-onset Sepsis in Neonates.
Geraerds AJLM, van Herk W, Stocker M, El Helou S, Dutta S, Fontana MS, Schuerman FABA, van den Tooren-de Groot RK, Wieringa J, Janota J, van der Meer-Kappelle LH, Moonen R, Sie SD, de Vries E, Donker AE, Zimmerman U, Schlapbach LJ, de Mol AC, Hoffman-Haringsma A, Roy M, Tomaske M, Kornelisse RF, van Gijsel J, Visser EG, van Rossum AMC, Polinder S.
Crit Care. 2021 Oct 20;25(1):367. doi: 10.1186/s13054-021-03789-x.
Bifidobacteria-mediated Immune System Imprinting Early in Life.
Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Kenckel E, Arzoomand A, Olin A, Wang J, Mikes J, Tan Z, Chen Y, Ehrlich AM, Berhardsson AK, Mugabo CH, Ambrosiani Y, Gustafsson A, Chew S, Brown HK, Prambs J, Bohlin K, Mitchell RD, Underwood MA, Smilowitz JT, German JB, Frese SA, Brodin P.
Cell. 2021 Jul 22;184(15):3884-3898.e11. doi: 10.1016/j.cell.2021.05.030. Epub 2021 Jun 17.
C-reactive Protein, Procalcitonin and WBC to Rule Out Neonatal Early-onset Sepsis within 36 Hours: A Secondary Analysis of NeoPInS Study.
Stocker M, Van Herk W, El Helou S, Dutta S, Fontana MS, Schuerman FABA, Van den Tooren-de Groot RK, Wieringa JW, Janota J, Van der Meer-Kappelle LH, Moonen R, Sie SD, De Vries E, Donker AE, Zimmerman U, Schlapbach LJ, De Mol AC, Hoffman-Haringsma A, Roy M, Tomaske M, Kornelisse RF, Van Gijsel J, Visser JG, Achten N, Plötz FB, Heath P, Lehnick D, Van Rossum AMC for the NeoPInS Study Group.
Clin Infect Dis. 2021 Jul 15;73(2):e383-e390. doi: 10.1093/cid/ciaa876.
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.
Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, Tan Z, Zicari S, Ruggiero A, Pascucci GR, Santilli V, Campbell T, Bryceson Y, Eriksson D, Wang J, Marchesi A, Lakshmikanth T, Campana A, Villani A, Rossi P, the CACTUS study team, Landegren N, Palma P, Brodin P.
Cell. 2020 Nov 12;183(4):968-981.e7. doi: 10.1016/j.cell.2020.09.016. Epub 2020 Sep 6.
Development of the Gut Microbiota in Early Life: The Impact of Cystic Fibrosis and Antibiotic Treatment.
Kristensen M, Prevaes SMPJ, Kalkman G, Tramper-Stranders GA, Hasrat R, De Winter- de Groot KM, Janssens HM, Tiddens HA, Van Westreenen M, Sanders EAM, Arets B, Keijser B, Van der Ent CK, Bogaert D.
J Cyst Fibros. 2020 Jul;19(4):553-561. doi: 10.1016/j.jcf.2020.04.007. Epub 2020 May 30.
A Genome-wide Transcriptomic Analysis of Protein-coding Genes in Human Blood Cells.
Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
Science. 2019 Dec 20;366(6472):eaax9198. doi: 10.1126/science.aax9198.
Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis.
Achten NB, Klingenberg C, Benitz WE, Stocker M, Schlapbach LJ, Giannoni E, Bokelaar R, Driessen GJA, Brodin P, Uthaya S, van Rossum AMC, Plötz FB.
JAMA Pediatr. 2019 Nov 1;173(11):1032-1040. doi: 10.1001/jamapediatrics.2019.2825.
Impact of Delivery Mode-associated Gut Microbiota Dynamics on Health in the First Year of Life.
Reyman M, Van Houten MA, Van Baarle D, Bosch AATM, Man WH, Chu MLJN, Arp K, Watson RL, Sanders EAM, Fuentes S, Bogaert D.
Nat Commun. 2019 Nov 1;10(1):4997. doi: 10.1038/s41467-019-13014-7.
A Call for Blood - in Human Immunology.
Brodin P, Duffy D, Quintana-Murci L.
Immunity. 2019 Jun 18;50(6):1335-1336. doi: 10.1016/j.immuni.2019.05.012.
The Repertoire of Maternal Antiviral Antibodies in Human Newborns.
Pou C*, Nkulikiyimfura D*, Henckel E, Olin A, Lakshmikanth T, Mikes J, Wang J, Chen Y, Bernhardsson AK, Gustafsson A, Bohlin K, Brodin P.
Nat Med. 2019 Apr;25(4):591-596. doi: 10.1038/s41591-019-0392-8. Epub 2019 Mar 18.
Neonatal Sepsis of Early-onset, and Hospital-acquired and Community-acquired Late Onset: A Prospective Population-based Cohort Study.
Giannoni E, Agyeman P, Stocker M, Posfay-Barbe KM, Heiniger U, Spycher BD, Bernhad-Stirnemann S, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Riedel T, Kuehni C, Aebi C, Berger C, Schlapbach LJ.
J Pediatr. 2018 Oct;201:106-114.e4. doi: 10.1016/j.jpeds.2018.05.048. Epub 2018 Jul 24.
Impact of Empowering Leadership on Antimicrobial Stewardship: A Single Center Study in a Neonatal and Pediatric Intensive Care Unit and a Literature Review.
Steinman KE, Lehnick D, Buettcher M, Schwendener-Scholl K, Daetwyler K, Fontana M, Morgillo D, Ganassi K, O'Neill K, Genet P, Burth S, Savoia P, Terheggen U, Berger C, Stocker M.
Front Pediatr 2018 Oct 12;6:294. doi: 10.3389/fped.2018.00294. eCollection 2018.
Culture-negative Early-onset Sepsis - At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship.
Klingenberg C, Kornelisse RF, Buoncore G, Maier RF, Stocker M.
Front Pediatr. 2018 Oct 9;6:285. doi: 10.3389/fped.2018.00285. eCollection 2018.
Neonatal Ventilator Associated Pneumonia: A Quality Improvement Initiative Focusing on Antimicrobial Stewardship.
Goerens A, Lehnick D, Buettcher M, Daetwyler M, Fontana M, Genet P, Lura M, Morgillo D, Pilgrim SB, Schwendener-Scholl K, Regamey N, Neuhaus TJ, Stocker M.
Front Pediatr. 2018 Sep 24;6:262. doi: 10.3389/fped.2018.00262. eCollection 2018.
Stereotypic Immune Systeme Development in Newborn Children.
Olin A*, Henckel E*, Chen Y, Tadepally L, Pou C, Mikes J, Gustafsson A, Berhardsson AK, Zhang C, Bohlin K, Brodin P.
Cell. 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045.
Time-to-positivity of Blood Cultures in Children with Sepsis.
Dierig A, Berger C, Agyeman P, Bernhard-Steinmann S, Giannoni E, M Stocker, K Posfay-Barbe, A Niederer-Loher, CR Kahlert, A Donas, P Hasters, C Relly, T Riedel, C Aebi, Schlapbach LJ, Heiniger U.
Front Pediatr. 6:222:2018 doi: 10.3389/fped.2018.00222
Procalcitonin-guided Decision Making for Duration of Antibiotic Therapy in Neonates with Suspected Early-onset Sepsis: A Multicentre, Randomised Controlled Trial (NeoPIns).
Stocker M, Van Herk W, El Helou S, Dutta S, Fontana MS, Schuerman FABA, Van den Tooren-de Groot RK, Wieringa JW, Janota J, Van der Meer-Kappelle LH, Moonen R, Sie SD, De Vries E, Donker AE, Zimmerman U, Schlapbach LJ, De Mol AC, Hoffman-Haringsma A, Roy M, Tomaske M, Kornelisse RF, Van Gijsel J, Visser EG, Willemsen SP, Van Rossum AMC, and the NeoPInS Study Group
The Lancet. 2017 Aug 26;390(10097):871-881. doi: 10.1016/S0140-6736(17)31444-7. Epub 2017 Jul 12.
Continuous Immunotypes Describe Human Immune Variation and Predict Diverse Responses.
Kaczorowski K, Shekhar K, Nkulikiyimfura D, Dekker C, Maecker H, Davis M, Chakraborty A, Brodin P.
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6097-E6106. doi: 10.1073/pnas.1705065114.
Recognising Early Onset Neonatal Sepsis: An Essential Step in Appropriate Antimicrobial Use.
Van Herk W, Stocker M, Van Rossum AM.
J Infect. 2016 Jul 5;72 Suppl:S77-82. doi: 10.1016/j.jinf.2016.04.026. Epub 2016 May 21.
Variation in Current Management Term an Late-preterm Neonates at Risk for Early-onset Sepsis.
Van Herk W, El Heloh S, Janota J, Hagmann C, Klingenberg C, Staub E, Giannoni E, Tissieres P, Schlapbach LJ, Van Rossum AMC, Pilgrim SB, Stocker M.
Pediatr Infect Dis J. 2016 May;35(5):494-500. doi: 0.1097/INF.0000000000001063
Incidence and Outcome of Group B Streptococcal Sepsis in Infants in Switzerland.
E Giannoni, C Berger, M Stocker, P Agyeman, KM Posfay-Barbe, U Heiniger, G Konetzny, A Niederer-Loher, CR Kahlert, A Donas, A Leone, P Hasters, C Relly, W Baer, C Aebi, LJ Schlapbach.
Pediatr Infect Dis J. 2016 Feb;35(2):222-4. doi: 10.1097/INF.0000000000000974.
Variations in the Human Immune System is Largely Driven by Non-heritable Influences.
Brodin P, Jojic V, Gao T, Bhattacharya S, Lopez Angel CJ, Furman D, Shen-Orr S, Dekker CL, Swan GE, Butte AJ, Maecker HT, Davis MM.
Cell. 2015 Jan 15;160(1-2):37-47. doi: 10.1016/j.cell.2014.12.020.
Pancreatic Stone Protein as a Novel Marker for Neonatal Sepsis.
Schlapbach LJ, Graf R, Woerner A, Fontana M, Zimmermann-Baer U, Glauser D, Giannoni E, Roger T, Müller C, Nelle M, Stocker M.
Intensive Care Med. 2013 Apr;39(4):754-63. doi: 10.1007/s00134-012-2798-3. Epub 2013 Jan 8.
Neonatal Procalcitonin Intervention Study (NeoPInS): Effect of Procalcitonin-guided Decision Making on Duration of Antibiotic Therapy in Suspected Neonatal Early-onset Sepsis: A Multi-centre Randomized Superiority and Non-inferiority Intervention Study.
Stocker M, Hop WC, van Rossum AM.
BMC Pediatr. 2010 Dec 8;10:89. doi: 10.1186/1471-2431-10-89.
Use of Procalcitonin-guided Decision-making to Shorten Antibiotic Therapy in Suspected Neonatal Early-onset Sepsis: Prospective Randomized Intervention Trial.
Stocker M, Fontana M, El Helou S, Wegscheider K, Berger TM.
Neonatology. 2010;97(2):165-74. doi: 10.1159/000241296.Epub 2009 Sep 24.